The test detects genetic predisposing factors for hereditary breast cancer and ovarian cancer.
The tumour suppressor genes BRCA1 and BRCA2 encode the BRCA proteins responsible for genome stability, which also regulate homologous recombination as well as cell growth and cell division in the repair of DNA defects. Mutation of both alleles is required for the risk of tumour development and genetic susceptibility.
According to current studies, based on meta-analysis of 10 studies in hereditary breast and ovarian cancer syndrome (HBOC), there is a nearly 57% chance of developing breast cancer before the age of 70 in an individual carrying the mutation in case of BRCA1 gene mutation, while when it comes to BRCA2 gene, it is 49%.
In case of ovarian cancer, also comparing several studies, these numbers might turn out in the following way: 40% risk of developing ovarian cancer in case of BRCA1 gene mutation and an 18% risk when it comes to BRCA2 gene mutation.