The physician may request the determination of the level of ceruloplasmin if Wilson’s disease is suspected in case of the following symptoms: jaundice, fatigue, anaemia, behavioural disorder, nausea, tremors, etc.
Rarely, it might be ordered with a copper test if copper deficiency is suspected, but also for the diagnosis of Menkes syndrome (X chromosome-related recessively inherited copper deficiency).
A blood sample taken from a vein is needed for the test.
Low levels of ceruloplasmin may indicate Wilson’s disease and Menkes syndrome, however, it is not enough to determine the level of ceruloplasmin to diagnose the former, further tests are required.
Elevated levels of ceruloplasmin are caused by, among other things, inflammation, infections, and cancer, but also pregnancy and taking oral contraceptives.