Beta-crosslaps is also called as collagen cross-linking or BCL. Collagen type I is present in the material composition of the human skeleton, which is responsible for its strength. During the normal process of bone metabolism, type I collagen particles break down into so-called fragments, then enter the bloodstream and are excreted through the kidneys.
During our lives, bone-breaking and bone-building cells are involved in bone metabolism, and normally they are in balance. Beta-cross laps perform the breaking down mechanism.
What does the test show?
The beta-crosslaps laboratory test examines the bone building and bone breakdown processes in the human skeletal structure. By determining metabolic activity, the beta-crosslaps isomer is a specific indicator of type 1 collagen degradation. With increased bone resorption, its concentration in the blood increases, which means that the activity of bone-breaking cells increase, while bone-building cells decrease.
In which cases is it recommended?
When osteoporosis is suspected, in addition to beta-crosslaps, the mineral composition of the bone stock is also examined, which includes vitamin D, calcium, and phosphate items. In older age, it is also recommended in case bone fracture occurs frequently.
What sample is needed for the test?
A blood sample taken from a vein is needed for the test.
What can the result indicate?
In case of increased bone resorption, its concentration in the blood increases. However, it is important to emphasize that by using several diagnostic procedures, we can be sure whether we are actually dealing with osteoporosis. This can be a bone density test, a laboratory test for bone metabolism, or another imaging diagnostic procedure.
What to do after the arrival of your results?
The test alone cannot diagnose any disease, and in all cases consult a rheumatologist to determine the exact diagnosis and therapy required.