It is important to emphasize that a diagnosis can only be made by examining several values together, be it a complete liver function test or a bone metabolism test.
High ALP level usually indicates damage to the liver or the skeletal system. If liver tests, performed at the same time, such as bilirubin, GOT, or GPT levels are also elevated, ALP is derived from the liver. If phosphate and calcium levels are abnormal, then ALP is of bone origin.
Primarily, elevated alkaline phosphatase levels are of greater clinical significance, which may be caused by the following diseases:
- Liver cancer
- Hepatic cirrhosis (alcohol-induced liver damage)
- Inflammation of the liver (hepatitis)
- Gallstones, biliary stagnation
Elevations in ALP activity are also common during pregnancy.
The following abnormalities may be behind the decreased value:
- lack of certain vitamins and minerals: folic acid, vitamin C, vitamin D, vitamin B6, phosphate, zinc