The immune response developing after coronavirus infection and vaccination has several manifestations, which expands the possibility of laboratory measurements. After coronavirus infection, the function of one of the cellular elements of the immune system, the B lymphocyte, can be measured by the IgG antibodies produced. Antibodies to coronavirus spike protein (S protein) or nucleocapsid protein (N protein) can be tested. However, experience has shown that there are patients in whom no antibody can be detected after coronavirus infection. We also see that antibody levels decrease over time and fall below the detection limit. After vaccinations, we see the same phenomenon.
A laboratory test of the function of another cellular element of the immune system, the T cells, is suitable for showing the body’s immune response even in the absence of a measurable antibody.
In this test, we reconstruct an infection under laboratory conditions in which infection-dominant fragments of the coronavirus are present, without the virus’s genome. The assay measures the responses of different T cells (CD4 helper T, CD8 suppressor T).
We examine the immune response after infection and in case of patients who are patients vaccinated against coronavirus (Moderna, Pfizer, Astra Zeneca, Sputnik, Sinopharm) with a test of 4 types of proteins. The results are evaluated.
We recommend the T-cell test:
- in long-COVID disease without antibody
- to confirm that an infection has occurred if no antibody is detected
- to assess cellular immune response after COVID vaccination in negative antibody cases
- after recovery and vaccination to assess the long-term immune response
Turnaround time: 14 working days.
The price of the test: 43 000 HUF