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APC resistance

APC resistance – activated protein C resistance – is a common inherited lesion that can lead to deep vein thrombosis (a blood clot in one of the body’s deep-running veins).

What is the purpose of the test?

The APC resistance test is used to detect Leiden mutation, the most common genetic predisposing factor for thrombosis. Because of the mutation, the protein chain of activated coagulation factor V cannot be broken down by an enzyme called activated protein C (APC). Due to the slowing down of the breakdown of coagulation factors, the patient’s blood clots are more coagulated and therefore prone to thrombosis.

In which cases is it recommended to perform the test?

  • In case of recurrent thrombosis or embolism
  • After thrombosis at a young age
  • If thrombosis occurs in an unusual place (lower limb, deep veins)
  • Due to a frequent thrombotic event (familial occurrence) in the family

What type of sample is needed for the test?

A blood sample taken from a vein or an oral mucosal swab is required to perform the test.

What can the result indicate?

In case of a positive result, it is recommended to perform a genetic test.

What to do after the test?

Based on the results of the laboratory test, an accurate diagnosis cannot be made yet. In all cases, please consult the specialist who ordered the test or a doctor who has experience in treating coagulation diseases.

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